Cardioprotective Effects of High-Density Lipoproteins
نویسندگان
چکیده
منابع مشابه
Cardioprotective Effects of High-Density Lipoproteins
The fact that a low level of high-density lipoprotein (HDL) cholesterol is highly predictive of future cardiovascular events has been established in population studies beyond all reasonable doubt. Furthermore, the evidence is overwhelming that the relationship is one of cause and effect rather than an epiphenomenon, with numerous studies in animals demonstrating that HDL-raising interventions t...
متن کاملSynthetic high-density lipoproteins exert cardioprotective effects in myocardial ischemia/reperfusion injury.
Human high-density lipoproteins (HDLs) protect the heart against ischemia/reperfusion injury. In the present study, the cardioprotective effects of synthetic high-density lipoproteins (sHDLs) made of phosphatidylcholine and apolipoprotein A-I were investigated in isolated rat hearts, which underwent a 20-min low-flow ischemia followed by a 30-min reperfusion. The administration of sHDL during t...
متن کاملEffects of inflammation on high-density lipoproteins.
High-density lipoproteins (HDLs) protect against the development of atherosclerotic coronary heart disease.1 In part, this reflects the ability of HDL to promote the efflux of cholesterol from macrophages in the artery wall2 but given that atherosclerosis is an inflammatory disorder,3 it may also reflect anti-inflammatory properties of HDL.4,5 Conversely, inflammation reduces the concentration ...
متن کامل[High-density lipoproteins].
the accurate mechanism of how EIIC transports a sugar has not been clearly demonstrated yet. To investigate more detailed and accurate transportation mechanisms, we performed collective variable-based steered molecular dynamics (CVSMD) simulations. Our simulation shows the spontaneous transportation of the sugar toward the opposite side of the membrane with the preserved H-bonding interactions,...
متن کاملMaturation of high-density lipoproteins.
Human high-density lipoproteins (HDLs) are involved in the transport of cholesterol. The mechanism by which HDL assembles and functions is not well understood owing to a lack of structural information on circulating spherical HDL. Here, we report a series of molecular dynamics simulations that describe the maturation of discoidal HDL into spherical HDL upon incorporation of cholesterol ester as...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000172634.93210.5c