Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action
نویسندگان
چکیده
منابع مشابه
Anti-atherogenic Functions of High Density Lipoproteins
HDL has many protective activities against atherosclerosis including its role in reverse cholesterol transport, and its antioxidant, anti-inflammatory, and endothelial cell maintenance functions. Various HDL subclasses vary in quantitative and qualitative content of lipids, apolipopropteins, enzymes, and lipid transfer proteins, resulting in differences in shape, density, size, charge, and anti...
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Apolipoprotein A-I (apoA-I) mimetic peptides may represent an alternative to apoA-I for large-scale production of synthetic high-density lipoproteins (sHDL) as a therapeutic agent. In this study, the cardioprotective activity of sHDL made with either L37pA peptide or its d-stereoisomer, D37pA, was compared to sHDL made with apoA-I. The peptides were reconstituted with palmitoyl-oleoyl-phosphati...
متن کاملCardioprotective Effects of High-Density Lipoproteins
The fact that a low level of high-density lipoprotein (HDL) cholesterol is highly predictive of future cardiovascular events has been established in population studies beyond all reasonable doubt. Furthermore, the evidence is overwhelming that the relationship is one of cause and effect rather than an epiphenomenon, with numerous studies in animals demonstrating that HDL-raising interventions t...
متن کاملBeyond High-Density Lipoprotein Cholesterol Levels
A number of therapeutic strategies targeting high-density lipoprotein (HDL) cholesterol and reverse cholesterol transport are being developed to halt the progression of atherosclerosis or even induce regression. However, circulating HDL cholesterol levels alone represent an inadequate measure of therapeutic efficacy. Evaluation of the potential effects of HDL-targeted interventions on atheroscl...
متن کاملAnti-atherogenic and anti-inflammatory properties of high-density lipoprotein are affected by specific antibodies in systemic lupus erythematosus.
OBJECTIVE To determine whether antibodies against high-density lipoprotein (aHDL) and apolipoprotein A-I (aApo A-I) interfere with the anti-atherogenic functions of high-density lipoprotein (HDL) and relate to disease activity and damage in SLE. METHODS Seventy-seven SLE patients were compared with an age- and sex-frequency matched control group. Immunoglobulin G (IgG) aHDL, IgG aApoA-I, solu...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2018
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.rv17025