منابع مشابه
cardiac biomarkers: a focus on cardiac regeneration
historically, biomarkers have been used in two major ways to maintain and improve better health status: first, for diagnostic purposes, and second, as specific targets to treat various diseases. a new era in treatment and even cure for the some diseases using reprograming of somatic cells is about to be born. in this approach, scientists are successfully taking human skin cells (previously co...
متن کاملCardiac Regeneration
Since Robert Gross inaugurated pediatric cardiac surgery in 1938 and since the advent of open-heart surgery on cardiopulmonary bypass in the 1950s, mortality from congenital heart disease has plummeted. However, many of the more complex forms of congenital heart disease still cannot be physiologically corrected; rather, patients are surgically palliated, permitting survival but leaving signific...
متن کاملReprogramming for cardiac regeneration
Treatment of cardiovascular diseases remains challenging considering the limited regeneration capacity of the heart muscle. Developments of reprogramming strategies to create in vitro and in vivo cardiomyocytes have been the focus point of a considerable amount of research in the past decades. The choice of cells to employ, the state-of-the-art methods for different reprogramming strategies, an...
متن کاملRegeneration in Cardiac Muscle.
Proliferation of striated muscle, either in the form of regeneration of damaged tissue or hyperplasia of relatively normal cells, is generally thought not to occur. Such an opinion is an example of the general idea that more " specialized " tissues differ from less " differentiated " tissues in that they are unable to multiply in adult life. This proposition, however, has gradually become more ...
متن کاملMicroRNAs and Cardiac Regeneration.
The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling by fibroblasts, resulting in the eventual deterioration of cardiac structure and function. Cardiac function would be improved if these fibroblasts could be converted into cardiomyocytes. MicroRNAs (miRNAs), small no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2015
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.3254