CARCINOGENIC POLLUTANTS o-NITROANISOLE AND o-ANISIDINE ARE SUBSTRATES AND INDUCERS OF CYTOCHROMES P450
نویسندگان
چکیده
منابع مشابه
Carcinogenic pollutants o-nitroanisole and o-anisidine are substrates and inducers of cytochromes P450.
2-Methoxyaniline (o-anisidine) and 2-methoxynitrobenzene (o-nitroanisole) are important pollutants and potent carcinogens for rodents. o-Anisidine is oxidized by microsomes of rats and rabbits to N-(2-methoxyphenyl)hydroxylamine that is also formed as the reduction metabolite of o-nitroanisole. o-Anisidine is a promiscuity substrate of rat and rabbit cytochrome P450 (CYP) enzymes, because CYPs ...
متن کاملCytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole
N-(2-methoxyphenyl)hydroxylamine is a human metabolite of the industrial and environmental pollutants and bladder carcinogens 2-methoxyaniline (o-anisidine) and 2-methoxynitrobenzene (o-nitroanisole). Here, we investigated the ability of hepatic microsomes from rat and rabbit to metabolize this reactive compound. We found that N-(2-methoxyphenyl)hydroxylamine is metabolized by microsomes of bot...
متن کاملOxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 – similarity between human and rat enzymes
2-Nitroanisole (2-NA) is an important industrial pollutant and a potent carcinogen for rodents. Understanding which cytochrome P450 (CYP) enzymes are involved in its metabolism are important to assess an individual's susceptibility to this environmental carcinogen. The aim of this study was to evaluate the efficiency of rat hepatic CYPs to oxidize 2-NA, to examine the metabolites formed during ...
متن کاملO-Anisidine Degradation by Fenton’s Reagent and Reaction Time Estimation
O-Anisidines (OAs) are extensively used as an intermediate for chemical reactions to produce various triphenylmethane and azo dyes, and also in manufacturing numerous pigments. They are found to be highly toxic and have carcinogenic properties, so it is imperative to treat OA solutions before disposal. In this study a promising approach to degrade OA solutions has been carried out using Fenton’...
متن کاملO-Anisidine Degradation by Fenton’s Reagent and Reaction Time Estimation
O-Anisidines (OAs) are extensively used as an intermediate for chemical reactions to produce various triphenylmethane and azo dyes, and also in manufacturing numerous pigments. They are found to be highly toxic and have carcinogenic properties, so it is imperative to treat OA solutions before disposal. In this study a promising approach to degrade OA solutions has been carried out using Fenton’...
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ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2005
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2005.077