Carboxybetaine and Carboxybetaine Ester Derivatives of Tetra(dodecyloxyphenyl)-calix[4]resorcinarene: Synthesis, Self-Assembly and In Vitro Toxicity

Amphiphilic calix[4]resorcinarenes are a class of macrocyclic compounds with broad potential utility including nanomedicine. Here the synthesis new carboxybetaine and ester calix[4]resorcinarene bearing 4-(dodecyloxy)phenyl groups on lower rim is presented. The were characterized by 1H-NMR, 13C-NMR, 2D NMR, IR, ESI elemental analysis. critical association concentration values 1.00 × 10−5 1.18 mol·L−1 for carboxybetain ester, respectively. hemolytic activity macrocycles their cytotoxicity against normal (WI-38, Chang liver) tumor cells (M-HeLa) also estimated.