Carbonyl-Olefin Metathesis for the Synthesis of Cyclic Olefins
نویسندگان
چکیده
منابع مشابه
Tandem Olefin Metathesis/Oxidative Cyclization: Synthesis of Tetrahydrofuran Diols from Simple Olefins.
A tandem olefin metathesis/oxidative cyclization has been developed to synthesize 2,5-disubstituted tetrahydrofuran (THF) diols in a stereocontrolled fashion from simple olefin precursors. The ruthenium metathesis catalyst is converted into an oxidation catalyst in the second step and is thus responsible for both catalytic steps. The stereochemistry of the 1,5-diene intermediate can be controll...
متن کاملFullerene-templated synthesis of a cyclic porphyrin trimer using olefin metathesis.
An olefination approach to the construction of covalently linked cyclic metalloporphyrin trimers is presented using fullerenes such as C(60) or C(70) as a template. Yields of the trimer approach 60%. In the absence of a template, the major product is the cyclic dimer (50% yield) with only a small amount of trimer (<10%) formed, indicating this is a template-directed approach.
متن کاملApplication of olefin metathesis in the synthesis of steroids.
Over the past decade, ruthenium-mediated metathesis transformations, including cross-metathesis, ring-closing metathesis, enyne metathesis, ring-opening metathesis polymerization, and also tandem processes, belong to the most intensively studied reactions. Many applications of olefin metathesis in the synthesis of natural products have been recently described. Also in the field of steroid chemi...
متن کاملSynthesis, structure, and activity of enhanced initiators for olefin metathesis.
A series of ruthenium olefin metathesis catalysts of the general structure (H(2)IMes)(PR(3))(Cl)(2)Ru=CHPh (H(2)IMes = 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene) have been prepared; these complexes are readily accessible in two steps from commercially available (H(2)IMes)(PCy(3))(Cl)(2)Ru=CHPh. Their phosphine dissociation rate constants (k(1)), relative rates of phosphine reassociation, and ...
متن کاملSynthesis and reactivity of olefin metathesis catalysts bearing cyclic (alkyl)(amino)carbenes.
The evolution of olefin metathesis into a reaction routinely used to form new carbon–carbon double bonds has been enabled by the development of well-defined transition-metal catalysts. [1,2] Many metathesis catalysts based on the [L2X2Ru=CHR] scaffold have been synthesized in an effort to increase catalyst stability, activity, and substrate scope.[3–10] A significant gain in these areas was ach...
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ژورنال
عنوان ژورنال: Organic Syntheses
سال: 2018
ISSN: 2333-3553
DOI: 10.15227/orgsyn.095.0472