Carbonic anhydrases activation with 3-amino-1H-1,2,4-triazole-1-carboxamides: Discovery of subnanomolar isoform II activators
نویسندگان
چکیده
منابع مشابه
5-Amino-3-methyl-1-phenyl-1H-1,2,4-triazole
In the title compound, C(9)H(10)N(4), the phenyl and triazole rings make a dihedral angle of 38.80 (2)°. N-H⋯N hydrogen bonds link the mol-ecules, forming centrosymmetric R(2) (2)(8) rings; these rings are inter-connected through a C(5) chain, building up a zigzag layer parallel to the (100) plane.
متن کاملCorrosion Protection of Copper with Hybrid Sol-Gel Containing 1H-1, 2, 4-triazole-3-thiol
To improve the corrosion protection of copper metal, 0.01M concentration of 1H-1,2,4-triazole-3-thiol (TAT) was incorporated into the hybrid sol-gel monolayers containing 3-glycidoxypropyltrimethoxysilane (GPTMS) and Tetraethoxysilane (TEOS). It was further subjected to hydrolysis and condensation reaction to form a sol-gel matrix. The TAT-doped hybrid sol-gel coating was applied over the c...
متن کاملAcetylation of methyl 5-amino-1H-[1,2,4]triazole-3-carboxylate.
Acetylation with acetic anhydride of methyl 5-amino-1H-[1,2,4]triazole-3-carboxylate, one of the hetareneamino acids, was studied using HPLC, H NMR, FTIR and GC-MS. The compound has a significantly decreased susceptibility to acetylation compared to 5-amino-1H-[1,2,4]triazole itself. Two isomeric diacetylated products were found.
متن کاملTransport metabolons with carbonic anhydrases
THE CONCEPT OF THE TRANSPORT METABOLON A metabolon has been defined as a “temporary, structural-functional, supramolecular complex of sequential metabolic enzymes and cellular structural elements, in which metabolites are passed from one active site to another without complete equilibration with the bulk cellular fluids” (Srere, 1985, 1987). This substrate channeling should decrease transit tim...
متن کامل4-Amino-3-phenyl-1H-1,2,4-triazole-5(4H)-thione
In the title compound, C(8)H(8)N(4)S, the planar triazole ring forms a dihedral angle of 13.7 (2)° with the phenyl ring. The crystal structure is stabilized by inter-molecular N-H⋯S hydrogen-bond inter-actions, linking the mol-ecules into chains along the a axis.
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2017
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2017.01.031