منابع مشابه
Designing Anti-cancer Drugs and Directing Anti-cancer Drug Therapy
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S. S. Kesharwani, P. Muley, S. Kumar, F. El Kourati, H. Tummala South Dakota State University Purpose Micelles offer several advantages for the delivery of hydrophobic drugs including a ‘core-shell’ delivery system for drug targeting. A plethora of polymers have been investigated for micellar delivery systems. Polyethylene glycol (PEG) forms the hydrophilic part of most of these amphiphilic pol...
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The number of physical conditions and chemical agents induce accumulation of misfolded proteins creating proteotoxic stress. This leads to activation of adaptive pro-survival pathway, known as heat shock response (HSR), resulting in expression of additional chaperones. Several cancer treatment approaches, such as proteasome inhibitor Bortezomib and hsp90 inhibitor geldanamycin, involve activati...
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The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase and the founding member of a signaling pathway that regulates many fundamental features of cell growth and division. In cells, mTOR acts as the catalytic subunit of two functionally distinct complexes, called mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2). Together, these complexes coordinate a ...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2004
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.19.51