Capture the fracture - use of bone turnover markers in clinical practice

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Capture the fracture – Use of bone turnover markers in clinical practice

Miljanka VUKSANOVIĆ Kliničko odeljenje za endokrinologiju, dijabetes i bolesti metabolizma Interna klinika Kliničko-bolnički centar „Zvezdara“ Dimitrija Tucovića 161 11000 Beograd Srbija [email protected] SUMMARY Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per year. Bone remodeling is a well-balanced process of bone resorption, induced by osteoc...

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Bone-turnover markers in fracture healing.

Biochemical markers of bone-turnover have long been used to complement the radiological assessment of patients with metabolic bone disease. Their implementation in daily clinical practice has been helpful in the understanding of the pathogenesis of osteoporosis, the selection of the optimal dose and the understanding of the progression of the onset and resolution of treatment. Since they are de...

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Biochemical markers of bone turnover: why theory, research, and clinical practice are still in conflict.

In metabolic bone diseases other than osteoporosis (Paget disease, rickets and osteomalacia, primary and secondary hyperparathyroidism), biochemical markers of bone turnover have been important clinical tools in patient management for more than 3 decades. In these diseases, bone metabolism is often so abnormal that even crude, nonspecific markers such as total serum alkaline phosphatase and uri...

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Bone turnover markers.

Bones are constantly remodelled to cope with the body's calcium requirements and to repair microscopic damage. The entire skeleton is replaced every 10 years in adults, and around 10% of the skeleton is involved in bone remodelling at any one time.

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Clinical application of biochemical markers of bone turnover.

With the ageing population in most countries, disorders of bone and mineral metabolism are becoming increasingly relevant to every day clinical practice. Consequently, the interest in, and the need for effective measures to be used in the screening, diagnosis and follow-up of such pathologies have markedly grown. Together with clinical and imaging techniques, biochemical tests play an important...

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ژورنال

عنوان ژورنال: Srpski arhiv za celokupno lekarstvo

سال: 2016

ISSN: 0370-8179,2406-0895

DOI: 10.2298/sarh1608450v