منابع مشابه
Capillary Basal Lamina Thickening
Thickening of basal lamina' (BL) which occurs with advancing age (1) and various diseases (4, 7, 10) is most common and severe in patients with diabetes mellitus (2, 8, 6, 12, 14) . The reasons, for. and the mechanism of this thickening have thus far escaped satisfactory explanation . In this communication, we wish to provide new evidence which elucidates the development of thick BL and which d...
متن کاملCablin: a novel protein of the capillary basal lamina.
The microvascular wall is remarkably simple, consisting only of the endothelial lining, subjacent basal lamina, and underlying periendothelial cells. This study describes the characterization of a novel microvascular protein. This 80,000-molecular weight protein was predominantly associated with electron-lucent amorphous material in capillary basal laminae and therefore termed cablin (protein o...
متن کاملIs thickening of the basal lamina in the saphenous vein a hallmark of smoking?
OBJECTIVE To investigate whether smoking causes ultrastructural changes in the intima of the proximal saphenous vein. DESIGN Proximal saphenous veins from heavy smokers and non-smokers were examined with scanning and transmission electron microscopy to determine changes in surface ultrastructure, in the intercellular junction, and in the thickness of the basal lamina. Immunogold labelling was...
متن کاملPhosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia
Citation: Nydegger C, Martinelli C, Di Marco F, Bulfamante G, von Segesser L, Tozzi P, Samaja M and Milano G (2018) Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia. Front. Physiol. 9:289. doi: 10.3389/fphys.2018.00289 Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in ...
متن کاملBasal lamina heterogeneity in the glomerular capillary tufts of human kidneys
Two classes of glomerular basal laminas are identified with a newly developed guanidine technique. The electron-opaque epithelial basal lamina is the most prominent element of the glomerular basal lamina scaffold. It is a continuous layer within each glomerulus, folding into capillary tufts and loops, but never completely encircling the entire circumference of each capillary, similar to the ser...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1970
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.47.1.281