منابع مشابه
Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs
Since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role of the cannabinoid system in immunity and the inflammatory response in human tissues and animal models. Although the cannabinoid system is present and crucial in many human tissues, studying the impact of cannabinoids on the lungs is particularly relevant because of their co...
متن کاملCancer therapy-The role of cannabinoids and endocannabinoids
Cannabinoids have recently been added to the therapeutic armamentarium of cancer, not only for their palliative effects (inhibition of chemotherapy-induced nausea and vomiting) but also as antitumor drugs, based on their ability to induce cancer cell apoptosis and reduce neoangiogenesis as well as tumor cell invasiveness and metastasis. A large number of researches have reported the antitumor e...
متن کاملCannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators.
Cannabinoids-endocannaboids are possible preventatives of common diseases including cancers. Cannabinoid receptors (CB(½), TRPV1) are central components of the system. Many disease-ameliorating effects of cannabinoids-endocannabinoids are receptor mediated, but many are not, indicating non-CBR signaling pathways. Cannabinoids-endocannabinoids are anti-inflammatory, anti-proliferative, anti-inva...
متن کاملDifferential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids.
Endocannabinoid release from a single neuron has been shown to cause presynaptic inhibition of transmitter release at many different sites. Here, we demonstrate that hypothalamic proopiomelanocortin (POMC) neurons release endocannabinoids continuously under basal conditions, unlike other release sites at which endocannabinoid production must be stimulated. The basal endocannabinoid release sele...
متن کاملAcute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb: Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release
We studied the effects of cannabinoids and acute immobilization stress on the regulation of GABA release in the olfactory bulb. Glutamate-stimulated 3H-GABA release was measured in superfused slices. We report that cannabinoids as WIN55, 212-2, methanandamide, and 2-arachidonoylglycerol were able to inhibit glutamate- and KCl-stimulated 3H-GABA release. This effect was blocked by the CB1 antago...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2020
ISSN: 1662-5099
DOI: 10.3389/fnmol.2020.00125