Candidate RNA biomarkers in biofluids for early diagnosis of ovarian cancer: A systematic review

Ovarian cancer is often diagnosed in an advanced stage and associated with a high mortality rate. It assumed that early detection of ovarian could improve patient outcomes. Unfortunately, effective screening methods for diagnosis are still lacking. Extracellular RNAs circulating human biofluids can reliably be measured emerging as potential biomarkers cancer. In this systematic review, we present 75 RNA detectable have been studied The majority these markers microRNAs identified using RT-qPCR or microarrays blood-based fluids. A handful studies used RNA-sequencing explored alternative fluids, such urine ascites. Candidate were more abundant patients compared to controls at least two independent include miR-21, the miR-200 family, miR-205, miR-10a miR-346. Amongst confirmed lower miR-122, miR-193a, miR-223, miR-126 miR-106b. While show promising diagnostic potential, further validation required before implementation routine clinical care. Challenges related biomarker reflections on future perspectives accelerate progress field discussed.