Candesartan decreases the sympatho-adrenal and hormonal response to isolation stress
نویسندگان
چکیده
منابع مشابه
Hypothalamic-pituitary-adrenal-axis vs. the sympatho-adrenal medullary system in the acute response to psychological stress
........................................................................................................................................ III Opsomming .................................................................................................................................... V Acknowledgements .................................................................................................
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Angiotensin II, which stimulates AT(1) receptors, is a brain and peripheral stress hormone. We pretreated rats with the AT(1) receptor antagonist candesartan for 13 d via sc-implanted osmotic minipumps, followed by 24-h isolation in individual metabolic cages. We measured angiotensin II receptor-type binding and mRNAs and tyrosine hydroxylase mRNA by quantitative autoradiography and in situ hyb...
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There would appear sound evidence on which to incriminate sustained sympatho-adrenal hyperactivity as a deleterious factor of prime importance in hypovolaemic shock. The use of sympathomimetics in the treatment of shock of this type is irrational and deleterious. Their rational use in those few cases of clinical shock where they are indicated will have to await knowledge of plasma catecholamine...
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The results obtained in the study showed that sheep subjected to a new stress factor (restraint) following twice-applied action of another stress factor (isolation from the flock), maximum ACTH concentration was considerably higher than in the group of sheep subjected to single restraint stress, whereas the values of maximum cortisol concentration were similar. It distinctly indicated a diverge...
متن کاملSympatho-adrenal stimulation by carbon dioxide and the inhibitory effect of carbonic acid on epinephrine response.
Carbon dioxide serves as a potent stimulus to increase the titer of circulating sympatho-adrenal catechol amines in the cat. Using the denervated nictitating membrane as an assay method the CO2 threshold for adrenal stimulus was determined to be about 1.57~ concentration in alveolar air. Adrenalectomy decreased by 600/, the catechol amine titer initiated by 307~ COS, but hepatectomy was ineffec...
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ژورنال
عنوان ژورنال: Journal of the Renin-Angiotensin-Aldosterone System
سال: 2001
ISSN: 1470-3203,1752-8976
DOI: 10.1177/14703203010020012301