Cancer therapeutics: Personal experiences and future perspectives

Peptide nucleic acid: Current perspectives and application for future therapeutics

Peptide nucleic acid (PNA) is a deoxyribonucleic acid (DNA) mimic based on a polyamide backbone first synthesized and reported by Peter Nielsen in 1991. PNA shows remarkable hybridization properties and has many exciting applications. It is chemically and biologicaly stable and can readily conjugate with peptides and other useful molecules. The search for new chemical modification of the PNA is...

Bacterial and tissue biomarkers of gastric cancer: new findings and future perspectives: review article

Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide. It has been proposed that the specific genotypes of Helicobacter pylori (H. pylori) are the causative agents in the development of gastroduodenal diseases, such as chronic atrophic gastritis, peptic ulcerations, and GC. However, disease progression to GC occurs in only a small proportion of infected patients. Re...

Aptamer Therapeutics in Cancer: Current and Future

Aptamer-related technologies represent a revolutionary advancement in the capacity to rapidly develop new classes of targeting ligands. Structurally distinct RNA and DNA oligonucleotides, aptamers mimic small, protein-binding molecules and exhibit high binding affinity and selectivity. Although their molecular weight is relatively small-approximately one-tenth that of monoclonal antibodies-thei...

Membrane Engineering: Future Perspectives

Selecting Research Topics: Personal Experiences and Speculations For the Future

In the rapidly changing field of information systems, every researcher faces important choices about what research topics to explore and how to pursue that research. This paper addresses these questions by summarizing a panel discussion at the 2001 Decision Sciences Institute (DSI) annual meeting. The first part of this paper provides a framework explaining factors that can be used in selecting...