Cancer-associated fibroblasts support bone tropic metastasis by acting as coordinators between the tumor microenvironment and bone matrix in breast cancer

Bone is a common site of metastasis for various types cancer cells, including breast cancer, and the consequent skeleton-related events observed in patients are severe often fatal. Currently, it widely accepted that cancer-associated fibroblasts (CAFs) confer metastasis-promoting property to cells. Furthermore, clinical observations suggest CAFs mediate bone tropism metastatic Therefore, deeper understanding mechanism by which involved bone-tropic can facilitate study novel effective therapeutic drugs corresponding targets. In this review, we focused on coordinator role remolding cells remodeling marrow during metastasis. We discussed potential roles CXCL12/CXCR4 axis, CAFs-CSCs reinforcing loop, exosomes malignant process. summary, agreement with Paget's theory, play pivotal colonization providing fertile soil selected seeds influencing tumor-intrinsic characteristics microenvironment (ME).