Can immune monitoring help to minimize immunosuppression in kidney transplantation?
نویسندگان
چکیده
منابع مشابه
Immunosuppression in kidney transplantation
For most patients with chronic kidney failure, kidney transplantation has the greatest potential for restoring a healthy and productive life. The risk of acute rejection is the highest in the first months after transplantation (induction phase) and diminishes afterwards (maintenance phase). Immunosuppression should be at the highest level in the early period and reduced for long-term therapy. A...
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The past decade has witnessed the introduction of several new immunosuppressive agents. The availability of these new agents has led to attempts to determine which is the best combination of maintenance immunosuppression for the patients, based on efficacy and reduction of adverse effects. Steroid avoidance, withdrawal and minimization regimens are being assessed. Calcineurin withdrawal or mini...
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Background: The aim of this study was to use the volume of the graft as an adjunct tool for better decision making. Methods: Kidney transplanted patients with acute azotemia and documented volume and finally a biopsy were enrolled in this study. Graft volumes between rejected patients (antibody-mediated rejection {AMR} and cell - mediated rejection {CMR}) and non rejected but azotemic patien...
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The initial results of kidney transplantation were significantly affected by a high rate of acute rejection as well as significant perioperative morbidity. Historically, the armamentarium of the transplant physician consisted of glucocorticoids and azathioprine. Significant improvements in the science and understanding of kidney transplantation immunology have lead to the development of inducti...
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W E RECENTLY reported our initial experience with FK 506 in 36 patients undergoing renal transplan-tation. 1 This series was characterized by a high average complexity. and included 10 patients who also were liver recipients either concomitantly or at an earlier time. Additionally , 2 of the 10 also were given a heart or pancreas. We report here a follow-up of the 26 patients from that original...
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ژورنال
عنوان ژورنال: Transplant International
سال: 2009
ISSN: 0934-0874,1432-2277
DOI: 10.1111/j.1432-2277.2008.00748.x