Can HIV p24 Be a Suitable Scaffold for Presenting Env Antigens?

Can HIV p24 be a suitable scaffold for presenting Env antigens?

Efforts to elicit protective immunity to HIV have resulted in unsatisfactory results (reviewed in reference 24). In particular, the elicitation of broadly reactive and cross-clade neutralizing antibodies (NAbs) represents an unprecedented challenge because of the intrinsic property of HIV to generate molecular and antigenic variants, escaping the immune surveillance (4). However, cross-reactive...

HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens

Heterologous protein scaffolds engrafted with structurally defined HIV Env epitopes recognized by broadly neutralizing monoclonal antibodies (MAbs) represent a promising strategy to elicit broad neutralizing antibodies. In such regards, a protein scaffold based on the HIV p24 CA protein is a highly attractive approach, providing also Gag epitopes for eliciting HIV non-neutralizing protective an...

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A suitable data model for HIV infection and epidemic detection

Background: In recent years, there has been an increase in the amount and variety of data generated in the field of healthcare, (e.g., data related to the prevalence of contagious diseases in the society). Various patterns of individuals’ relationships in the society make the analysis of the network a complex, highly important process in detecting and preventing the incidence of diseases....

Ridesharing in Muscat: Can it be a Sustainable Solution for the Traffic Congestion?

We deal with developing a Decision Support System (DSS) to promote the ridesharing among both students and staff of a big organization. The DSS includes a set of functions that allow the management of the riders’ requests and drivers’ availability and embeds a novel two-phase optimization approach that helps in defining the optimal riders-drivers matching. The first phase consists o...