Can HIV incidence testing be used for evaluating HIV intervention programs? A reanalysis of the Orange Farm male circumcision trial (ANRS-1265)
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Can HIV incidence testing be used for evaluating HIV intervention programs? A reanalysis of the Orange Farm male circumcision trial (ANRS-1265)
BACKGROUND The objective of this study was to estimate the effect of male circumcision (MC) on HIV acquisition estimated using HIV incidence assays and to compare it to the effect measured by survival analysis. METHODS We used samples collected during the MC randomized controlled trial (ANRS-1265) conducted in Orange Farm (South Africa) among men aged 18 to 24. Among the 2946 samples collecte...
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متن کاملRandomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial
BACKGROUND Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND FINDINGS A total of 3,274 uncircumcised men, aged 18-24 y, were randomized to a control or an intervention group with follow-up visits at months 3, ...
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Background There is an urgent need to intensify and expand HIV prevention strategies, with an estimated 33.4 million people living with HIV in 2008 and an estimated 2.7 million newly infected. New infections continue to outstrip advances made in numbers treated – for every 2 people put on antiretroviral therapy, another 5 become infected. Current strategies to reduce sexual transmission of HIV ...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2010
ISSN: 1471-2334
DOI: 10.1186/1471-2334-10-137