Can Cryoprotectant’s modification in Spermatozoa Cryopreservation be an Alternative to Improve Embryo Quality? A Review

Spermatozoa cryopreservation is an effective method for maintaining male fertility in humans. Nevertheless, there are some limitations of sperm cryopreservation, which called as cell injury by cryoprotectant, that cannot be avoided. This process will affect embryo quality. Therefore, it mandatory to modify cryoprotectant spermatozoa improve review aimed summarize the modification can damage cell, thereby improving To this purpose, a computerized search EMBASE, PubMed, Scopus and Google Scholar databases from 2008 2022 were performed on general term such “sperm cryopreservation”, “cryoprotective agent”, “modified cryoprotectant”, “cell injury”. Of these, 1847 publications screened 38 articles obtained evaluated. Although no formal conclusions drawn regarding obtain good quality, our results suggest modified cryoprotectants alternative compared commercial cryoprotectants. In addition, use antioxidant also prevent due negative effects However, further researches still need investigate cellular mechanisms.