Can Bottom-Up Synthetic Biology Generate Advanced Drug-Delivery Systems?

Bottom-up synthetic biology: modular design for making artificial platelets.

Engineering artificial cells to mimic one or multiple fundamental cell biological functions is an emerging area of synthetic biology. Reconstituting functional modules from biological components in vitro is a challenging yet an important essence of bottom-up synthetic biology. Here we describe the concept of building artificial platelets using bottom-up synthetic biology and the four functional...

Can Bottom-Up Institutional Reform Improve Service Delivery?

Synthetic Microbes As Drug Delivery Systems

Synthetic cell therapy is a field that has broad potential for future applications in human disease treatment. Next generation therapies will consist of engineered bacterial strains capable of diagnosing disease, producing and delivering therapeutics, and controlling their numbers to meet containment and safety concerns. A thorough understanding of the microbial ecology of the human body and th...

Novel transdermal drug delivery systems

Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...

Top-down versus bottom-up—rediscovering physiology via systems biology?

Systems biology is the latest fashion in biology, driven by advances in technology that have provided us with a suite of ‘omics’ techniques providing information or at least data, which is not quite the same thing, but can easily be confused with it at a whole range of levels of biomolecular organisation from genes through proteins to metabolites. The hope is that all of these, when combined in...