Can a Selective Serotonin Reuptake Inhibitor Act as a Glutamatergic Modulator?
نویسندگان
چکیده
منابع مشابه
Can a Selective Serotonin Reuptake Inhibitor Act as a Glutamatergic Modulator?
Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft. However, the biological effects of these drugs seem to be more complex than their traditionally described mechanism of action. Among their actions is the inhibiti...
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Background and Purpose The aim of the study was to investigate the efficacy and safety of the selective serotonin reuptake inhibitor citalopram in treating poststroke depression, since available treatments are usually poorly tolerated. Methods A 6-week double-blind, placebo-controlled trial was undertaken. Diagnosis and outcome were determined using the Hamilton Depression Scale, and unwanted e...
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Volume 23, Issue 9 June 2008 1 Major depressive disorder (MDD) is characterized as a disabling psychiatric disorder, presenting with a loss of pleasure and interest in activities that normally bring satisfaction and enjoyment. MDD is a common disorder, roughly occurring at least once in the lifetime of 16.2% of US adults (32.6-35.1 million people), and at least once in the past year of 6.6% of ...
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Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed in the treatment of depression and anxiety, as well as obsessive-compulsive, eating, and impulse-control disorders. Paralleling their widespread use has been an increase in adverse-effect reports not noted during short-term efficacy studies. Significant among these adverse effects is SSRI discontinuation syndrome, which follo...
متن کاملSelective serotonin reuptake inhibitor-induced apathy: a pediatric case series.
OBJECTIVES Selective serotonin reuptake inhibitor (SSRI)-induced apathy is characterized by a lack of motivation that is not a result of sedation or symptoms of depression. This report describes two pediatric cases of SSRI-induced apathy, one of which is the first reported case in a child with a non-OCD (obsessive compulsive disorder) anxiety disorder. METHODS The sample included 43 participa...
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ژورنال
عنوان ژورنال: Current Therapeutic Research
سال: 2017
ISSN: 0011-393X
DOI: 10.1016/j.curtheres.2017.07.001