Caloric restriction: Impact upon pituitary function and reproduction
نویسندگان
چکیده
منابع مشابه
Adiposity and comorbidities: favorable impact of caloric restriction.
The focus here is on research involving long-term calorie restriction (CR) to prevent or delay the incidence of the metabolic syndrome with age. The current societal environment is marked by overabundant accessibility of food coupled with a strong trend to reduced physical activity, both leading to the development of a constellation of disorders including central obesity, insulin resistance, dy...
متن کاملCaloric restriction in humans.
Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a protective effect against secondary aging, and markedly decreases the incidence of malignancies. However, the only way to determine whether CR "works" in humans is to conduct studies on people. Such studies are difficult to perform in free-living people. While research on CR in humans is still at...
متن کامل[Caloric restriction and anti-aging].
エレガンス線虫の寿命は約 3 週間で寿命の遺伝学的解 析に適している.研究室で実験に使っている野生型線虫 (N2)は,20°C で飼育すると,最大寿命が 21 日前後な ので,10 日目には中年特有の表現系を示すことが知ら れている.実際,顕微鏡で観察すると,10 日目には消 化管の周りの脂肪組織が急に黒ずんで目立つようにな る.この症状は脂肪細胞にトリグリセライドの蓄積が増 加するためで,ヒトにおける中年太りの内臓脂肪の蓄積 によく似た症状である. 代表的な長寿線虫,daf-2 変異体は最も遺伝解析が進 んでいる変異体である.daf-2 線虫は耐性幼虫(dauer) になりやすいことから daf(dauer formation,耐性幼虫 化)シリーズの名前が付いている.しかし,運動やリズ ムは正常で,一定温度(高温)で飼育する限り,耐性幼 虫化せずに,寿命は 1.5 倍~2 倍に延...
متن کاملCaloric restriction and its mimetics
Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being con...
متن کاملCaloric restriction and genomic stability
Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age. This hypothesis is attractive because the integrity of the genome is es...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ageing Research Reviews
سال: 2008
ISSN: 1568-1637
DOI: 10.1016/j.arr.2008.01.002