Calmodulin Binding to Connexin 35: Specializations to Function as an Electrical Synapse
نویسندگان
چکیده
منابع مشابه
Identification of the calmodulin binding domain of connexin 43.
Calmodulin (CaM) has been implicated in mediating the Ca(2+)-dependent regulation of gap junctions. This report identifies a CaM-binding motif comprising residues 136-158 in the intracellular loop of Cx43. A 23-mer peptide encompassing this CaM-binding motif was shown to bind Ca(2+)-CaM with 1:1 stoichiometry by using various biophysical approaches, including surface plasmon resonance, circular...
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The controversy as to whether synaptic transmission in the central nervous system is electrical or chemical played a key role in the origin of modern neuroscience, and I shall attempt to give it a historical perspective. Almost 100 years ago (1886--1890) it was recognized by several neuroanatomists, including His, Ford, and Ram6n y Cajal, that nerve cells or neurons were independent biological ...
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The binding of calcium-calmodulin (CaM) to caldesmon (CaD) contributes to the regulation of smooth muscle contraction. It has been reported that a 17-residue synthetic peptide encompassing the residues Gly651-Ser667 of smooth muscle CaD constitutes its CaM-binding domain [Zhan, Q., Wong, S. S., & Wang, C.L.A. (1991) J. Biol. Chem. 266, 21810-21814]. This peptide does not share sequence homology...
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In the recent paper (2011) Faas and co-workers claimed that calmodulin could directly detect Ca 2+ signals by acting as extremely fast calcium buffer. However the results and their interpretation raise serious doubts about this conclusion. The major concerns are:-The on-rate constant for calcium binding by calmodulin (CaM) has not been directly measured and was instead found via Markovian fitti...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21176346