California gives radiation-safety violations a short half-life

Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and rescue of IgG3 is inhibited in the presence of IgG1 due to intracellular competition between IgG1 and IgG3. We reveal that this occurs because of a single amino acid differen...

The Effectiveness of a Radiation Safety Training Program in Increasing the Radiation Safety Knowledge of Physicians: a Pilot Study

Background: Ionizing and non-ionizing radiation are widely used in the diagnosis and treatment of diseases. Considering the potential risks of radiation, radiation safety training courses are important for medical staff.  Objective: The aim of this study was to investigate the effectiveness of one-day radiation safety training program in increasing the radiation safety knowledge of physicians....

Residual Effects of Short Half-life Non-benzodiazepine Hypnotics

Background Since their introduction at the beginning of the 1990s the short half-life nonbenzodiazepine hypnotics, zolpidem and zopiclone, rapidly were among the most frequently prescribed hypnotics. Surveys showed that around 1996 the most frequently prescribed hypnotic in the US was zolpidem, while zolpidem and zopiclone were among the five most frequently used hypnotics in Europe [1, 2]. The...

CDC gives advice on tissue safety.

Quantification of intracardiac shunts by gold-195m, a new radionuclide with a short half life.

Gold-195m, a radionuclide with a short half life (30.5 s) was used to quantify left to right intracardiac shunts. The results of this method were compared with those obtained with technetium-99m, a method that was validated against oximetry. In five patients the pulmonary to systemic flow ratio (greater than 3:1) obtained by both radionuclides indicated that the level of shunting was too high t...