Calculations Show Substantial Serial Engagement of T Cell Receptors
نویسندگان
چکیده
منابع مشابه
Calculations show substantial serial engagement of T cell receptors.
The serial engagement model provides an attractive and plausible explanation for how a typical antigen presenting cell, exhibiting a low density of peptides recognized by a T cell, can initiate T cell responses. If a single peptide displayed by a major histocompatibility complex (MHC) can bind, sequentially, to different T cell receptors (TCR), then a few peptides can activate many receptors. T...
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1998). While these studies represent a clear step forward in defining the requirements for aggregation in initiating TCR signaling, they still leave several open questions. The first model does not explain how a few complexes (say, less than 10) per APC might rapidly trigger T cells, while the second does not account for CD8-independent Switzerland responses. What is ultimately important is to ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2001
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(01)76041-9