Calculation of the Median Lethal Dose and Low Lethal Dose Using the CombiStats Biometric Software
نویسندگان
چکیده
The median lethal dose (LD 50 ) and low 10 are calculated in acute toxicity studies, as well during specific activity assessment of some medicines. aim the study was to develop a procedure for using CombiStats calculate LD . authors proposed step-by-step algorithm processing bioassay results biometric software (median effective determination model, probit analysis) with conversion doses simple fractions (fractions maximum dose) They compared calculation obtained those electronic spreadsheets according Bliss–Miller–Tainter–Prozorovsky method described State Pharmacopoeia Russian Federation (General Monograph 1.1.0014.15). It has been demonstrated that use sometimes advantages over pharmacoepoeial method.
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ژورنال
عنوان ژورنال: Vedomosti Nau?nogo centra èkspertizy sredstv medicinskogo primeneniâ
سال: 2021
ISSN: ['1991-2919', '2619-1172']
DOI: https://doi.org/10.30895/1991-2919-2021-11-2-135-142