Calcium-induced inactivation of calcium current causes the inter-burst hyperpolarization of Aplysia bursting neurones.
نویسندگان
چکیده
منابع مشابه
Calcium-induced inactivation of calcium current causes the inter-burst hyperpolarization of Aplysia bursting neurones.
A triphasic series of tail currents which follow depolarizing voltage-clamp pulses in Aplysia neurones L2-L6 was described in the preceding paper (Kramer & Zucker, 1985). In this paper, we examine the nature of the late outward component of the tail current (phase III) which generates the inter-burst hyperpolarization in unclamped cells. The phase III tail current does not reverse between -30 a...
متن کاملCalcium-dependent inactivation of the calcium current activated upon hyperpolarization of Paramecium tetraurelia
The Ca2+ current activated upon hyperpolarization of Paramecium tetraurelia decays over a period of 150-200 ms during sustained steps under voltage clamp. At membrane potentials between -70 and approximately -100 mV, the time course of this inactivation is described by a single exponential function. Steps negative to approximately -100 mV elicit currents that decay biexponentially, however. Thr...
متن کاملCalcium-dependent inactivation of a potassium current in the Aplysia neuron R15.
The endogenously bursting pacemaker neuron R15 of Aplysia exhibits an inwardly rectifying K+ current (IR) that was shown previously to be enhanced by various neurotransmitters via the intracellular second messenger, cyclic AMP (Drummond et al., 1980; Benson and Levitan, 1983; Levitan et al., 1987). Here we present evidence that Ca2+ influx, either caused by spontaneous bursting activity or elic...
متن کاملMechanism of calcium-dependent inactivation of a potassium current in Aplysia neuron R15: interaction between calcium and cyclic AMP.
In the preceding paper (Kramer and Levitan, 1988), we presented evidence that an inwardly rectifying K+ current (IR) is inactivated by Ca2+ influx accompanying spontaneous bursting activity in the Aplysia neuron R15. In this paper we examine the mechanism that enables Ca2+ to inactivate IR. Since IR is enhanced by cyclic AMP in neuron R15 (Drummond et al., 1980; Benson and Levitan, 1983), we ex...
متن کاملDopamine reduces slow outward current and calcium influx in burst-firing neuron R15 of Aplysia.
Dopamine's effect on calcium influx into the bursting neuron, R15, of Aplysia californica was tested by tail current measurements and by measurement of absorbance of intracellular Arsenazo III, a calcium-sensitive indicator. Slow outward tail currents were elicited by subthreshold depolarization in voltage clamp and were demonstrated to be dependent upon transient increases in intracellular cal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1985
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1985.sp015667