Calcium-dependent inactivation of calcium channels in cochlear hair cells of the chicken

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Calcium-dependent inactivation of calcium channels in cochlear hair cells of the chicken.

Voltage-gated calcium channels support both spontaneous and sound-evoked neurotransmitter release from ribbon synapses of cochlear hair cells. A variety of regulatory mechanisms must cooperate to ensure the appropriate level of activity in the restricted pool of synaptic calcium channels ( approximately 100) available to each synaptic ribbon. One potential feedback mechanism, calcium-dependent ...

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Modulation of voltage-gated calcium channels was studied in inner hair cells (IHCs) in an ex vivo preparation of the apical turn of the rat organ of Corti. Whole cell voltage clamp in the presence of potassium channel blockers showed inward calcium currents with millisecond activation and deactivation kinetics. When temperature was raised from 22 to 37 degrees C, the calcium currents of immatur...

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The inactivation of calcium channels in mammalian pituitary tumor cells (GHa) was studied with patch electrodes under voltage clamp in cell-free membrane patches and in dialyzed cells. The calcium current elicited by depolarization from a holding potential of 4 0 mV passed predominantly through one class of channels previously shown to be modulated by dihydropyridines and cAMP-dependent phospho...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 2007

ISSN: 0022-3751

DOI: 10.1113/jphysiol.2007.135582