Calcium antagonists and renal disease

Calcium antagonists and renal hemodynamics: implications for renal protection.

Recently, attention has focussed on the effects of calcium antagonists on renal function. When administered in vitro to the isolated perfused kidney, calcium antagonists exhibit consistent actions permitting characterization of their renal hemodynamic effects. Calcium antagonists do not affect the vascular tone of the vasodilated isolated perfused kidney, but they do dramatically reverse the re...

Calcium-channel antagonists in cardiovascular disease.

In the last 2 years there has been considerable controversy over the safety of certain calcium antagonists. This article discusses recent drug developments, summarizes the publications that sparked the controversy, highlights results of the l latest trials of calcium antagonists and considers the range of clinical conditions in which calcium antagonists may play a useful role.

Atherosclerosis, calcium, and calcium antagonists.

Calcium antagonists: effects on cardio-renal risk in hypertensive patients.

Calcium antagonists comprise 2 main subclasses, dihydropyridines and nondihydropyridines, and have been studied extensively in hypertensive patients. Early meta-analyses suggested that short-acting calcium antagonists were associated with higher mortality rates resulting from cardiovascular events and other etiologies. Recent meta-analyses failed to show any substantive difference between long ...

Clinical pharmacology of calcium antagonists. Satellite symposium on calcium antagonists.

A new class of agents has been made available for the treatment of hypertension. These calcium antagonists have rapid bioavailability and dramatic antihypertensive effects through reduction of total peripheral resistance and the vascular resistance of the major target organs of the body. These changes are usually associated with unchanged cardiac output, preserved organ blood flows, maintained ...