Calcium alginate microparticles containing anti-TB drugs

Inhalable microparticles containing large payload of anti-tuberculosis drugs.

Microparticles containing large payloads of two anti-tuberculosis (TB) drugs were prepared and evaluated for suitability as a dry powder inhalation targeting alveolar macrophages. A solution containing one part each of isoniazid and rifabutin, plus two parts poly(lactic acid) (L-PLA) was spray-dried. Drug content and in vitro release were assayed by HPLC, and DSC was used to elucidate release b...

Approaches to clinical trials of new anti - TB drugs

New drugs and drug combinations are urgently needed for shorter, more effective TB treatment. Standard regimens require treatment for at least 6 months and are difficult to complete in resource-constrained settings. Resistance to firstand second-line drugs is increasing in many areas and therefore drugs with new mechanisms of action are needed. These issues complicate clinical trials of new ant...

The effect of chitosan molecular weight on the properties of alginate/ chitosan microparticles containing prednisolone

Purpose: The aim of the present study was to investigate the effect of chitosan molecular weight on size, size distribution, release rate, mucoadhesive properties and electrostatic bonding of alginate/chitosan microparticles containing prednisolone Methods: Three mucoadhesive alginate/chitosan microparticle formulations, f1, f2 and f3, were prepared using low, medium and high chitosan molecular...

Anti Oxidative, Anti Peroxidative and Hepatoprotective Potential of Phyllanthus amarus Against Anti Tb Drugs

Using a microfluidic chip and internal gelation reaction for monodisperse calcium alginate microparticles generation.

In this paper, the manipulation of monodisperse Ca-alginate microparticles using a microfluidic chip and a reaction of internal gelation is presented. Our strategy is based on the sheath focusing effect to form uniform water-in-oil (w/o) emulsions in the cross-junction microchannel. These fine emulsions, consisting of 1.5 % w/v Na-alginate and 1.0 % w/v calcium carbonate, are then dripped into ...