Calcineurin, Synaptic Plasticity, and Memory
نویسندگان
چکیده
منابع مشابه
Neural functions of calcineurin in synaptic plasticity and memory.
Major brain functions depend on neuronal processes that favor the plasticity of neuronal circuits while at the same time maintaining their stability. The mechanisms that regulate brain plasticity are complex and engage multiple cascades of molecular components that modulate synaptic efficacy. Protein kinases (PKs) and phosphatases (PPs) are among the most important of these components that act ...
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Calcineurin is a calcium-dependent protein phosphatase that has been implicated in various aspects of synaptic plasticity. By using conditional gene-targeting techniques, we created mice in which calcineurin activity is disrupted specifically in the adult forebrain. At hippocampal Schaffer collateral-CA1 synapses, LTD was significantly diminished, and there was a significant shift in the LTD/LT...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2001
ISSN: 1537-744X
DOI: 10.1100/tsw.2001.259