Cadherin-mediated cell-cell interactions in normal and cancer cells
نویسندگان
چکیده
منابع مشابه
M-cadherin-mediated intercellular interactions activate satellite cell division.
Adult muscle stem cells and their committed myogenic precursors, commonly referred to as the satellite cell population, are involved in both muscle growth after birth and regeneration after damage. It has been previously proposed that, under these circumstances, satellite cells first become activated, divide and differentiate, and only later fuse to the existing myofiber through M-cadherin-medi...
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Human embryonal carcinoma (EC) cells typically require high cell densities to maintain their characteristic phenotype; they are generally subject to differentiation when cultured at low cell densities, marked by changes in morphology and expression of the surface antigen, SSEA-1. To test whether cadherin mediated cell-to-cell adhesion may be responsible for maintaining an EC phenotype we ascert...
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The adhesive function of classical cadherins depends on the association with cytoplasmic proteins, termed catenins, which serve as a link between cadherins and the actin cytoskeleton. LI-cadherin, a structurally different member of the cadherin family, mediates Ca2+-dependent cell-cell adhesion, although its markedly short cytoplasmic domain exhibits no homology to this highly conserved region ...
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During spermatogenesis, the differentiating germ cells migrate across the seminiferous epithelium while maintaining close contact with the surrounding Sertoli cells via specialized actin-based adherens junctions (ectoplasmic specializations) and intermediate filament-based anchoring junctions (desmosome-like junctions). Although this migration is essential for correct completion of spermatogene...
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ژورنال
عنوان ژورنال: Tissue Barriers
سال: 2017
ISSN: 2168-8370
DOI: 10.1080/21688370.2017.1356900