Ca2+sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries
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چکیده
منابع مشابه
Ca sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries
Juan Carlos Robles, Michael Sturek, Janet L. Parker, and Cristine L. Heaps Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices and Departments of Veterinary Physiology and Pharmacology and Small Animal Clinical Sciences, Texas A&M University, College Station; and Department of Systems Biology and Translational Medicine and Cardiovascular Research Institute...
متن کاملCa2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Exercise training enhances endothelium-dependent coronary vasodilatation, improving perfusion and contractile function of collateral-dependent myocardium. Paradoxically, studies from our laboratory have revealed increased Ca(2+)-dependent basal active tone in collateral-dependent arteries of exercise-trained pigs. In this study, we tested the hypothesis that exercise training enhances agonist-m...
متن کاملAltered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries.
Coronary arteries distal to chronic occlusion exhibit enhanced vasoconstriction and impaired relaxation compared with nonoccluded arteries. In this study, we tested the hypotheses that an increase in peak Ca(2+) channel current density and/or increased Ca(2+) sensitivity contributes to altered contractility in collateral-dependent coronary arteries. Ameroid occluders were surgically placed arou...
متن کاملAlterations in PKC signaling underlie enhanced myogenic tone in exercise-trained porcine coronary resistance arteries.
The intracellular mechanisms underlying enhanced myogenic contraction (MC) in coronary resistance arteries (CRAs) from exercise-trained (EX) pigs have not been established. The purpose of this study was to test the hypothesis that exercise-induced alterations in protein kinase C (PKC) signaling underlie enhanced MC. Furthermore, we sought to determine whether modulation of intracellular Ca(2+) ...
متن کاملDevelopment of endothelium-dependent relaxation in canine coronary collateral arteries.
BACKGROUND Little information exists regarding development of vasomotor control mechanisms during coronary collateral artery maturation. Therefore, we studied endothelium-dependent relaxation of canine collateral arteries isolated 2, 4, and 9 months after placement of an ameroid occluder around the proximal left circumflex coronary artery. RESULTS Collateral arteries isolated after 2 months e...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2011
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00957.2010