C50 VERY LONG TERM FOLLOW UP OF PRIMARY TRANSCATHETER PATENT FORAMEN OVALE CLOSURE FOR MIGRAINE CURE

Abstract Background Results of previous trials about PFO closure as a treatment for migraine are still doubtful and inconclusive. We sought to evaluate the long–term (>10 years) effectiveness by means patent foramen ovale (PFO) closure. Methods From 2006 2010, 86 patients (68 female, mean age 40.0 ±3.7 with disabling, medication–refractory were enrolled in prospective study over 48–month period. Criteria transcatheter all following: presence permanent right–to–left shunt (RLS) having shower/curtain pattern, interatrial septal aneurysm Eustachian valve, 3 4 class Migraine Disability Assessment Score (MIDAS), coagulation abnormalities, or without aura. Forty (46.5%) (34 females, 35.0±6.7 years, MIDAS 35.8 ± 4.7) underwent After follow–up 118.2 ±19.1 months (range 96 144), 37 continued experienced symptomatic improvement: aura was abolished totality along durable improvement throughout extended follow up also The significantly decreased group (p<0.0001) (Figure 1). Patients complete resolution presented shorter history migraine, more severe thrombophilic profile, RLS larger left atrial diameter volume. Conclusions Primary selected high–risk disabling refractory resulted abolition sustained reduction very