C3H strain of mouse mammary tumour virus, like GR strain, infects human mammary epithelial cells, albeit less efficiently than murine mammary epithelial cells
نویسندگان
چکیده
منابع مشابه
Mouse mammary tumor virus infects human cells.
Mouse mammary tumor virus (MMTV) has long been speculated to be involved in human breast cancer and more recently in human primary biliary cirrhosis. Despite complete proviral sequences markedly homologous to MMTV being identified in human breast cancer tissue, no convincing evidence has been presented to date that MMTV can infect human cells. Using both wild-type and a genetically marked virus...
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Previous studies have demonstrated that normal mammary tissue contains a hierarchy of cell types that are ultimately and continuously derived from a self-sustaining mammary stem cell population. However, a suitable assay for detecting, quantifying and characterizing such cells in humans has been lacking. Here we show that histologically normal, bi-layered mammary epithelial structures containin...
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Background: Staphylococci are recognized worldwide as one of the most important etiological agents of bovine mastitis due to their virulence factors such as their ability to penetrate inside mammary epithelial cells and their ability to form biofilm. Aims: The objectives of this study were to establish a model of primary mammary epithelial cells origin...
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Many receptors in hematopoietic cells use a common signaling pathway that relies on a highly conserved immunoreceptor tyrosine-based activation motif (ITAM), which signals through Src family tyrosine kinases. ITAM-bearing proteins are also found in many oncogenic viruses, including the mouse mammary tumor virus (MMTV) envelope (Env). We previously showed that MMTV Env expression transformed nor...
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Two kinds of droplets are revealed by the electron microscope in the milk, secretory alveoli, and epithelial cells of the lactating mammary gland of rats and mice (1-3). The larger droplets are fat and the smaller ones, measuring 30 to 400 m# in diameter, are primarily protein (4). The protein droplets first appear enclosed in vacuoles in the Golgi region; these vacuoles presumably pass through...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2015
ISSN: 0022-1317,1465-2099
DOI: 10.1099/jgv.0.000006