C2-Symmetric N-(.BETA.-Mercaptoethyl)pyrrolidine as a Chiral Catalyst Ligand in the Addition Reaction of Aldehydes and Diethylzinc.
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چکیده
منابع مشابه
Synthesis of novel C2-symmetric chiral bis(oxazoline) ligands and their application in the enantioselective addition of diethylzinc to aldehydes
Novel chiral bis(oxazoline) ligands bearing dibenzo[a,c]cycloheptadiene and a dihydroxy group have been synthesized and their application in the catalytic asymmetric addition of diethylzinc to aldehydes investigated. The enantioselectivities for the aromatic aldehydes are generally high and up to 96% ee was obtained. 2003 Elsevier Ltd. All rights reserved.
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The addition of dialkylzincs to aldehydes is one of the most widely studied carbon-carbon bond-forming reactions. Many systems reported to date use amino alcohols as ligands and zinc complexes as catalysts.1 The asymmetric version of this alkylation reaction can also be catalyzed by chiral titanate complexes2-4 (e.g., TADDOLs2 and chiral sulfonamides3). We have recently studied a titanate compl...
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15 صفحه اولSynthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes
A concise method for the preparation of new 3,4,5,6-tetrahydropyrimidinium salts was presented in this paper. Further application of these salts in asymmetric diethylzinc addition of arylaldehydes was explored, giving the corresponding chiral second alcohols in good yields and moderate enantioselectivities.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1996
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.44.454