C-peptide and Retinal Microangiopathy in Diabetes
نویسندگان
چکیده
منابع مشابه
C-peptide and Retinal Microangiopathy in Diabetes
Increased extracellular matrix (ECM) protein deposition and capillary basement membrane (BM) thickening are characteristic features of diabetic retinal microangiopathy. Recent observations in the authors' laboratories suggest that high glucose in endothelial cells as well as diabetes causes up-regulation of total fibronectin (FN), as well as extradomain-B (EDB) containing the spliced variant of...
متن کاملPlatelet aggregation and retinal microangiopathy in diabetes and hypertension.
Platelet aggregation studies were done in 10 cases of diabetes with and without retinopathy and 7 cases of hypertensive retinopathy with adenosine diphosphate (ADP) and adrenaline (ADR). It was observed that the rate and degree of aggregation was significantly increased in the retinopathy group both with ADP and ADR. A significant alteration in the latent period was found with ADP, whereas no s...
متن کاملC-Peptide as a Remedy for Diabetic Microangiopathy?
Insulin, connecting peptide (C-peptide) is part of the proinsulin molecule from which it is cleaved by a serine protease within the pancreatic b-cells and subsequently released in equimolar amounts with insulin (1–3). Primarily, C-peptide, which is predominantly cleared by the kidney, was regarded a biologically inert byproduct of insulin secretion and an unneeded contaminant of commercial insu...
متن کاملC-peptide in diabetes diagnosis and therapy.
C-peptide is known for several decades. It is released in equimolar amounts together with insulin from the pancreatic beta cells. Still there has been quite remarkable lack of interest in C-peptide. C-peptide is rarely used to classify type of diabetes although it seems self-evident that it is important to estimate the function of those cells which do not function good enough and therefore caus...
متن کاملGalactose-induced retinal microangiopathy in rats.
PURPOSE The suitability of the galactose-fed rat as a model of diabetic retinopathy was examined in nondiabetic rats fed diets enriched with either 30% or 50% galactose for up to 2 years. METHODS Retinal capillaries were examined by light and electron microscopy, and the prevalence or severity of diabetic-like lesions was quantitated. RESULTS Histologic evaluation of trypsin digests of reti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Diabesity Research
سال: 2004
ISSN: 1543-8600,1543-8619
DOI: 10.1080/15438600490424569