C-F bond activation under transition-metal-free conditions

Abstract The unique properties of fluorine-containing organic compounds make fluorine substitution attractive for the development pharmaceuticals and various specialty materials, which have inspired evolution diverse C-F bond activation techniques. Although many advances been made in functionalizations activated bonds utilizing transition metal complexes, there are fewer approaches available nonactivated due to difficulty oxidative addition metals inert bonds. In this regard, using Lewis acid abstract fluoride light/radical initiator generate radical intermediate emerged as powerful tools activating those Meanwhile, these transition-metal-free processes greener, economical, pharmaceutical industry, without heavy residues. This review provides an overview recent activations under conditions. key mechanisms involved demonstrated discussed detail. Finally, a brief discussion on existing limitations field our perspective presented.