C eacam1a −/− Mice Are Completely Resistant to Infection by Murine Coronavirus Mouse Hepatitis Virus A59
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منابع مشابه
Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus A59.
CEACAM1a glycoproteins are members of the immunoglobulin (Ig) superfamily and the carcinoembryonic antigen family. Isoforms expressing either two or four alternatively spliced Ig-like domains in mice have been found in a number of epithelial, endothelial, or hematopoietic tissues. CEACAM1a functions as an intercellular adhesion molecule, an angiogenic factor, and a tumor cell growth inhibitor. ...
متن کاملMice Are Completely Resistant to Infection by Murine Coronavirus Mouse Hepatitis Virus A59
Ceacam1a / Mice Are Completely Resistant to Infection by Murine Coronavirus Mouse Hepatitis Virus A59 Erin Hemmila, Claire Turbide, Melanie Olson, Serge Jothy, Kathryn V. Holmes,† and Nicole Beauchemin*† Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado, and McGill Cancer Centre and Departments of Biochemistry, Medicine, and Oncology, McGill University,...
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Mouse hepatitis virus A59 (MHV-A59) infection of adult BALB/c mice induced a severe, transient atrophy of the thymus. The effect was maximal at 1 week after infection, and thymuses returned to normal size by 2 weeks after infection. There was no effect of glucocorticoids, since thymus atrophy was also found in adrenalectomized, infected mice. In infected thymus, immature CD4+ CD8+ lymphocytes w...
متن کاملSeveral members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59.
Mouse hepatitis virus-A59 (MHV-A59), a murine coronavirus, can utilize as a cellular receptor MHVR, a murine glycoprotein in the biliary glycoprotein (BGP) subfamily of the carcinoembryonic antigen (CEA) family in the immunoglobulin superfamily (G.S. Dveksler, M. N. Pensiero, C. B. Cardellichio, R. K. Williams, G.-S. Jiang, K. V. Holmes, and C. W. Dieffenbach, J. Virol. 65:6881-6891, 1991). Sev...
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Antisera prepared against each of three single and one pair of major structural proteins of the bovine coronavirus (Mebus strain) were used in immunoblotting studies to measure cross-reactivity with the structural proteins of the human coronavirus OC43 and the mouse hepatitis coronavirus A59. We conclude that the bovine coronavirus is comprised of four major structural proteins, gp190 (normally...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2004
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.78.18.10156-10165.2004