C-46 | Novel Predictors and Clinical Outcomes of Permanent Pacemaker Placement (PPM) Following Transcatheter Aortic Valve Replacement (TAVR): A Midwest Rural Center Experience

BackgroundConduction and rhythm abnormalities requiring PPM are few of the complications following TAVR, their clinical outcomes remain unclear. The potential value novel predictors post-TAVR PPM, such as presence supraventricular arrhythmias, QRS duration, duration QTc is unclear.MethodsA retrospective cohort study patients with TAVR (January 2012-December 2019) was performed. group dichotomized into those without placement. Both groups were followed for one year.ResultsA total 357 included. mean age 80 years, 188 (52.7%) male 57 [16%] required a PPM. Baseline demographics, valve type, cardiovascular risk factors similar between groups. However Diabetes Mellitus type II (DMII) more prevalent in [59.6% vs 40.7%; P= 0.009]. had also significantly higher rate pre-procedure RBBB but not LBBB, prolonged > 120 ms, 470 arrhythmias. adjusted odds ratio heart failure hospitalization (aOR 2.2; CI; 1.1-4.3; P=0.022), myocardial infarction 3.9; 1.1-14; P=0.031) difference mortality at year.The necessity placement associated progressive widening QRS, which demonstrated by continuous increase (OR) every 20ms above 100ms: 101-120 [OR 2.44; 1.14-5.25; P=0.022], 121-140 3.25; 1.32-7.98; P=0.010], 141-160 6.98; 3.10-15.61; P<0.001]. After adjustments final model that remained significant DMII, [2.16; 1.18-3.94; P=0.012), QRS>120 [2.18; 1.02-4.66; P=0.045], marginally arrhythmias [1.82; 0.97-3.42; P=0.062].ConclusionsPre- DMII ms strong post Progressive beyond 100 increased need At 1-year have infarction.DisclosuresS. Nwaedozie Nothing to disclose. P. Sharma Yeung Umukoro D. Soodi J. Najjar Mojarrab H. Zhang R. Gabor Garcia-Montilla Conduction MethodsA year. A ResultsA P=0.062]. ConclusionsPre- infarction. Pre-