Bypass of DNA interstrand crosslinks by a Rev1–DNA polymerase ζ complex
نویسندگان
چکیده
منابع مشابه
Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link.
DNA interstrand cross-links (ICLs) are repaired in S phase by a complex, multistep mechanism involving translesion DNA polymerases. After replication forks collide with an ICL, the leading strand approaches to within one nucleotide of the ICL ("approach"), a nucleotide is inserted across from the unhooked lesion ("insertion"), and the leading strand is extended beyond the lesion ("extension"). ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2020
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkaa580