Butyrylcholinesterase, variants and metabolic syndrome
نویسندگان
چکیده
منابع مشابه
Novel Human Butyrylcholinesterase Variants: Toward Organophosphonate Detoxication
Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for stoichiometric binding and/or catalytic hydrolysis of organophosphates. Herein, we describe the use of a molecular evolution method to develop novel hBChE variants with increased resistance to stereochemically defined nerve agent model compounds of soman, sarin, and cyclosarin. Novel hBChE variants (Y3...
متن کاملButyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity.
BACKGROUND Plasma cholinesterase activity is known to be correlated with plasma triglycerides, HDL- and LDL-cholesterol, and other features of the metabolic syndrome. A role in triglyceride metabolism has been proposed. Genetic variants that decrease activity have been studied extensively, but the factors contributing to overall variation in the population are poorly understood. We studied plas...
متن کاملCorrelation between Diet Quality and Metabolic Syndrome
Background: The metabolic syndrome (MetS) is increasing with an alarming rate world wide. Since diet components' studies that focus on MetS have produced largely inconsistent results, assessing the whole diet than single nutrients on health can be more practical. The purpose of this study was to determine the association between diet quality and MetS components. Methods: This cross-sectional st...
متن کاملCorrelation between butyrylcholinesterase variants and sensitivity to soman toxicity.
Butyrylcholinesterase (BChE) is synthesized in the liver and found in high concentrations in blood plasma, liver, heart, pancreas, vascular endothelium, skin, brain white matter, smooth muscle cells and adipocytes. BChE is a non specific enzyme that hydrolyzes different choline esters (succinylcholine, mivacurium) and many other drugs such as aspirin, cocaine and procaine. The enzyme is also co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Adipobiology
سال: 2018
ISSN: 1313-3705,1313-3705
DOI: 10.14748/adipo.v9.4984