Burn-induced Heart Failure: Lipopolysaccharide Binding Protein Improves Burn and Endotoxin-Induced Cardiac Contractility Deficits
نویسندگان
چکیده
منابع مشابه
Burn-Induced Organ Dysfunction: Vagus Nerve Stimulation Improves Cardiac Function
INTRODUCTION Many studies have demonstrated the existence of an anti-inflammatory, parasympathetic pathway, termed as the inflammatory reflex. Burn-induced heart failure has been investigated in many previous studies. Proinflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, have been shown to play a key pathogenetic role and vagus nerve stimulation attenuates proinflammatory cytokine p...
متن کاملBurn-induced Bone Loss
OBJECTIVE The purpose of this article is to familiarize the reader with the issue of bone loss that accompanies severe burn injury. Why is this important? How does it happen? How can we treat it? METHODS The published findings on this subject are reviewed and integrated into a conceptual framework. RESULTS Bone loss occurs quickly following a severe burn, is sustained, and increases the ris...
متن کاملGhrelin improves burn-induced delayed gastrointestinal transit in rats.
Delayed gastrointestinal transit is common in patients with severe burn. Ghrelin is a potent prokinetic peptide. We aimed at testing the effect of ghrelin on burn-induced delayed gastrointestinal transit in rats. Gastric emptying (GE), intestinal transit (IT), and colonic transit (CT) studies were performed in male Sprague-Dawley rats. Rats were randomized into two main groups as follows: sham ...
متن کاملBurn plasma mediates cardiac myocyte apoptosis via endotoxin.
Thermal trauma is associated with cardiac myocyte apoptosis in vivo. To determine whether cardiac myocyte apoptosis could be secondary to burn-induced cytokines or inflammatory mediators, we investigated the effects of tumor necrosis factor-alpha (TNF-alpha) and burn plasma on a murine cardiac myocyte cell line and primary culture myocytes. HL-1 cells were exposed to plasma isolated from burned...
متن کاملRole of gut-lymph factors in the induction of burn-induced and trauma-shock-induced acute heart failure.
Acute injury-induced cardiac contractile dysfunction occurs even in young and otherwise healthy individuals after major injuries, and significantly contributes to morbidity and mortality in patients with pre-existent cardiac diseases as well as in patients who develop multiple organ dysfunction syndrome. Recent studies indicate that post-injury acute cardiac failure is the result of an exaggera...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2011
ISSN: 0022-4804
DOI: 10.1016/j.jss.2009.06.012