Building the vertebrate neuromuscular synapse
نویسندگان
چکیده
منابع مشابه
Building the vertebrate neuromuscular synapse.
Neuromuscular synapses form following a series of complex interactions between motor neurons, muscle fibers, and Schwann cells that culminate in the formation of a highly specialized postsynaptic membrane and a highly differentiated nerve terminal (Son and Thompson, 1995; Burden, 1998; Sanes and Lichtman, 2001; Schaeffer et al., 2001). In adult muscle, motor axon terminals are situated in shall...
متن کاملMHCI promotes developmental synapse elimination and aging-related synapse loss at the vertebrate neuromuscular junction.
Synapse elimination at the developing neuromuscular junction (NMJ) sculpts motor circuits, and synapse loss at the aging NMJ drives motor impairments that are a major cause of loss of independence in the elderly. Here we provide evidence that at the NMJ, both developmental synapse elimination and aging-related synapse loss are promoted by specific immune proteins, members of the major histocomp...
متن کاملElectrical Inexcitability of the Frog Neuromuscular Synapse
Frog muscle endplates were explored with an extracellular microelectrode. An intracellular microelectrode nearby simultaneously monitored invasion of the endplate by a spike directly evoked by a third microelectrode placed away from the endplate in the same fiber. External positivities were seen only at sites generating miniature endplate potentials. The external positivity reached a maximum pr...
متن کاملBuilding up the inhibitory synapse
“Building up the inhibitory synapse” is a complex phenomenon involving a variety of dynamically regulated molecular and cellular processes whose nature is still largely unknown. Understanding the role of different proteins in controlling synapses formation and stabilization may help elucidating, at the network level, the mechanisms by which inhibitory transmission controls network excitability ...
متن کاملTargeting Transcription to the Neuromuscular Synapse
Concomitant with innervation, genes coding for components of the neuromuscular junction become exclusively expressed in subsynaptic nuclei. A six-base pair element, the N box, can confer synapse-specific transcription to the acetylcholine nicotinic receptor delta and epsilon subunit, utrophin, and acetylcholine esterase genes. N box-dependent synaptic expression is stimulated by the nerve-deriv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurobiology
سال: 2002
ISSN: 0022-3034,1097-4695
DOI: 10.1002/neu.10137