منابع مشابه
Membrane-Spanning DNA Nanopores with Cytotoxic Effect**
DNA-based cytotoxic agents: Nanopores composed of folded DNA featuring a hydrophobic belt of ethyl phosphorothioate groups insert into bilayer membranes and kill cancer cells. The mode by which the pores achieve cell killing is elucidated with confocal microscopy.
متن کاملKinetics and mechanism of proton transport across membrane nanopores.
We use computer simulations to study the kinetics and mechanism of proton passage through a narrow-pore carbon-nanotube membrane separating reservoirs of liquid water. Free energy and rate constant calculations show that protons move across the membrane diffusively along single-file chains of hydrogen-bonded water molecules. Proton passage through the membrane is opposed by a high barrier in th...
متن کاملElectrostatics of ions inside the nanopores and trans-membrane channels
– A model of a finite cylindrical ion channel through a phospholipid membrane of width L separating two electrolyte reservoirs is studied. Analytical solution of the Poisson equation is obtained for an arbitrary distribution of ions inside the trans-membrane pore. The solution is asymptotically exact in the limit of large ionic strength of electrolyte on the two sides of membrane. However, even...
متن کاملStability and dynamics of membrane-spanning DNA nanopores
Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology. A fundamental question is how hydrophilic nanostructures reside in the hydrophobic environment of the membrane. Here, we use multiscale molecular dynamics (MD) simulations to explore the structure, stability and dynamics of an archetypical DNA nanotube inserted via a ring of membrane anchors into a phos...
متن کاملSpecialized membrane domains of plasmodesmata, plant intercellular nanopores
Plasmodesmata (PD) are plant-specific membrane-lined channels that connect neighboring cells across the cell wall and are indispensable for intercellular communication, development and defense against pathogens. They consist of concentric membrane tubules of the plasma membrane (PM) on the outside and endoplasmic reticulum (ER) on the inside. The biophysical properties and molecular composition...
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ژورنال
عنوان ژورنال: Nature Nanotechnology
سال: 2017
ISSN: 1748-3387,1748-3395
DOI: 10.1038/nnano.2017.99