منابع مشابه
Buccal absorption of ergotamine.
The rate of disappearance of ergotamine from the mouth after buccal administration has been studied in seven subjects. Allowance has been made for non-absorptive losses of the drug due to experimental technique. The absorption of ergotamine across the buccal mucosa appears to be a passive process, pH-dependent but independent of ergotamine concentration or the simultaneous presence of caffeine....
متن کاملErgotamine absorption and toxicity.
Adverse reactions to ergotamine were noted in 16 out of 41 studies in which therapeutic doses of the drug were given to normal, healthy volunteers. In 17 of the studies 0.25 mg ergotamine was given by injection, 6 i.v. and 11 i.m., in 20 studies 2 mg ergotamine was given by mouth, and 4 subjects received 2 mg ergotamine by suppository. Plasma and urinary ergotamine was measured by radio-immunoa...
متن کاملBuccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs.
The buccal administration of ergotamine tartrate (ET) combined with polyvinyl alcohol (PVA) gel brought about higher plasma concentration of ET compared with that of oral administration of capsules in guinea-pigs. T(max) of ET in plasma of buccal administration was significantly smaller than that of oral administration. For the buccal dosage form of ET, the bioadhesive tablet system (BTS) was n...
متن کاملAbsorption of vitamin C from the human buccal cavity.
1. Ascorbic acid was absorbed across the mucosa of the human mouth. 2. Omission of sodium ions from the medium decreased the absorption of ascorbic acid. 3. The presence of D-glucose, or 3-O-methyl-D-glucose, increased the absorption of ascorbic acid but D-fructose had little effect and D-mannitol had no effect. 4. Calcium ions also increased ascorbic acid absorption probably by a secondary ef...
متن کاملAbsorption of amino acids from the human buccal cavity.
appropriate controls the concentration of each amino acid could be established. The absence of glycylproline ( < 0 . 5 m ~ ) from the samples were established by t.1.c. From each of two to six animals a minimum of four sacs were prepared from the ileum. Examination of sacs after incubation by lightmicroscopy failed to show any disruption caused by the experimental procedure. Fig. ] ( a ) shows ...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1974
ISSN: 0022-3050
DOI: 10.1136/jnnp.37.10.1116