<b>Supraspinal antinociception by intracerebroventricular </b><b>administration of P2 purinoceptor agonists in rats </b>
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منابع مشابه
Direct assessment of renal microvascular responses to P2-purinoceptor agonists.
Studies were performed to determine the responsiveness of rat juxtamedullary afferent arterioles to receptor-selective P2-purinoceptor agonists. Experiments were performed in vitro using the blood perfused juxtamedullary nephron technique, combined with videomicroscopy. Renal perfusion pressure was set at 110 mmHg and held constant. Basal afferent arteriolar diameter averaged 22.0 ± 0.6 μm ( n ...
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BACKGROUND Alpha2 agonists contribute to pain control at the level of the medulla spinalis. Alpha2 agonists are generally added to local anaesthetics to prolong spinal or epidural anaesthesia time. AIMS In the present study, we aimed to evaluate the antinociceptive and neurotoxic effects of dexmedetomidine given intracerebroventricularly for 5 days. STUDY DESIGN Animal experimentation. ME...
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P2 purinoceptor modulation of injury during ischemia-reperfusion was studied in murine hearts. Effects of P2 agonism or antagonism, and interstitial accumulation of P2 agonists (UTP, ATP, and ADP), were assessed in Langendorff perfused hearts during 20 min of ischemia and 45 min of reperfusion. In control hearts, ventricular pressure development recovered to 68 +/- 4 mm Hg (63 +/- 3% baseline),...
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The functional interactions between supraspinal p, and 8 receptors were characterized in the mouse using p, receptor-selective antagonists. The effects of pretreatment with the p, opioid antagonists, /~-funaltrexamine (/'/-FNA) and naloxonazine on the modulation of morphine antinociception by the 8 agonists [D-PenZ,D-PenS]enkephalin (DPI)PE) and [D-AlaZ,MetS]enkephalinamide (DAMA) were studied....
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ژورنال
عنوان ژورنال: PAIN RESEARCH
سال: 2003
ISSN: 0915-8588,2187-4697
DOI: 10.11154/pain.18.115