منابع مشابه
Brown fat and vascular heat dissipation
Current efforts to treat obesity and associated disorders focus on the stimulation of energy expenditure by increasing thermogenesis, for instance through activating brown adipose tissue or more recently "beige" or "brite" fat, a relatively novel type of adipose tissue with putative thermogenic potential. In this commentary, we aim to provide an alternative perspective on the current trend of a...
متن کاملInappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1.
Thyroid hormone is a major regulator of thermogenesis, acting both in peripheral organs and on central autonomic pathways. Mice heterozygous for a point mutation in thyroid hormone receptor α1 display increased thermogenesis as a consequence of high sympathetic brown fat stimulation. Surprisingly, despite the hypermetabolism, their body temperature is not elevated. Here we show, using isolated ...
متن کاملBrown Fat in Humans: Turning up the Heat on Obesity
The looming pandemic of obesity and overweight, driven by ready access to high-calorie food and an increasingly sedentary way of life, poses a severe threat to global public health. The pathological accumulation of excess dysfunctional adipose tissue that characterizes obesity is a major risk factor for many other diseases, including type 2 diabetes, cardiovascular disease, hypertension, stroke...
متن کاملVascular rarefaction mediates whitening of brown fat in obesity.
Brown adipose tissue (BAT) is a highly vascularized organ with abundant mitochondria that produce heat through uncoupled respiration. Obesity is associated with a reduction of BAT function; however, it is unknown how obesity promotes dysfunctional BAT. Here, using a murine model of diet-induced obesity, we determined that obesity causes capillary rarefaction and functional hypoxia in BAT, leadi...
متن کاملBrown fat and thermogenesis.
Historical Background. ..................................................... 330 PhylogeneticDistribution .................................................. 332 AnatomyandTopology ................................................... 333 Vasculature of Brown Adipose Tissue. ...................................... 338 Microcirculation and vascularity .......................................... 338 G...
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ژورنال
عنوان ژورنال: Adipocyte
سال: 2014
ISSN: 2162-3945,2162-397X
DOI: 10.4161/adip.28815