Bromination of Pyrimidines by N-Bromosuccinimide. III. Bromination of Anilino-and Phenoxypyrimidines

Substrate Directed Regioselective Monobromination of Aralkyl Ketones Using N-Bromosuccinimide Catalysed by Active Aluminium Oxide: α-Bromination versus Ring Bromination

Bromination of aralkyl ketones using N-bromosuccinimide in presence of active Al2O3 provided either α -monobrominated products in methanol at reflux or mononuclear brominated products in acetonitrile at reflux temperature with excellent isolated yields depending on the nature of substrate employed. The α -bromination was an exclusive process when aralkyl ketones containing moderate activating/d...

Regioselective bromination of fused heterocyclic N-oxides.

A mild method for the regioselective C2-bromination of fused azine N-oxides is presented, employing tosic anhydride as the activator and tetra-n-butylammonium bromide as the nucleophilic bromide source. The C2-brominated compounds are produced in moderate to excellent yields and with excellent regioselectivity in most cases. The potential extension of this method to other halogens, effecting C2...

Bromination of Alkenes

The two most common halogenation reactions are chlorination and bromination. The addition of these halogens to alkenes yields 1,2-dihalides. Chlorinations reactions are used to synthesize over 6 million tons per year of ethylene dichloride (1,2-dichloroethane) for use as a solvent and for subsequent polymerization to produce poly(vinylchloride) known more commonly as PVC which is used for plumb...

Selective Mono Bromination of 1,4-Dihydropyridines

2-monobromomethyl 1,4-dihydropyridines is selectively synthesized by bromination of the parent compound by 1.1 equivalents of pyridinium bromide perbromide in dichloromethane/pyridine at -20 °C. The same reagent in dichloromethane at 0 °C produce the 2,6-bis(bromomethyl) 1,4-dihydropyridines.

Synthesis of enamines and their bromination