Broad segmental progeroid changes in short-lived Ercc1 −/Δ7 mice
نویسندگان
چکیده
منابع مشابه
Broad segmental progeroid changes in short-lived Ercc1−/Δ7 mice
Genome maintenance is considered a prime longevity assurance mechanism as apparent from many progeroid human syndromes that are caused by genome maintenance defects. The ERCC1 protein is involved in three genome maintenance systems: nucleotide excision repair, interstrand cross-link repair, and homologous recombination. Here we describe in-life and post-mortem observations for a hypomorphic Erc...
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Although it is clear that probiotics improve intestinal barrier function, little is known about the effects of probiotics on the aging intestine. We investigated effects of 10-week bacterial supplementation of Lactobacillus plantarum WCFS1, Lactobacillus casei BL23, or Bifidobacterium breve DSM20213 on gut barrier and immunity in 16-week-old accelerated aging Ercc1-/Δ7 mice, which have a median...
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ژورنال
عنوان ژورنال: Pathobiology of Aging & Age-related Diseases
سال: 2011
ISSN: 2001-0001
DOI: 10.3402/pba.v1i0.7219